#4006 ADDING 6-MONTH PARAMETERS FOR THE PREDICTION OF RENAL PROGNOSIS IN ANCA-ASSOCIATED GLOMERULONEPHRITIS

Abstract Background and Aims Antineutrophil-cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) with kidney involvement (AAV-GN) frequently evolves to end-stage disease (ESKD) despite aggressive immunosuppressive treatment. Several risk scores have been used assess renal prognosis. We aimed determine whether function markers of AAV-GN activity after 6 months could improve the prediction ESKD. Method This retrospective observational study included adult patients recruited from French nephrology centers (including Maine-Anjou AAV registry). The primary outcome was survival. Analyses were conducted in whole population a sub-population that did not develop ESKD early course disease. Results 241 cohort, median follow-up 59 months. At diagnosis, Berden classification Renal Risk Score (RRS) found better than (eGFR) alone, at predicting (C-index = 0.70, 0.79, 0.82, respectively). months, 20 reached In 221 patients, eGFR outperformed RRS 0.88, 0.62, 0.69, respectively) predict performed when it updated instead baseline eGFR. While 6-months proteinuria associated improved prediction, hematuria serological remission not. Conclusion work suggests interest reassessment prognosis diagnosis. Kidney this time remains most reliable for outcome. To long-term ESKD, there may be place repeated biopsy following induction treatment, order obtain precise evaluation activity, discuss treatment strategy scores.